The AI-Enabled Scientific Frontier

Gabriel Manso

Emma Fu

Neil Thompson

September 14, 2026
As artificial intelligence’s capabilities improve, it is increasingly viewed as a general scientific method. But how true are these claims? Does AI outperform all techniques, or only some, and how is this changing? To assess the claims, we assemble a corpus of 2,507 head-to-head comparisons between AI and other scientific analysis techniques across 27 scientific disciplines from papers published between 2000 and early 2025. We find a profound dichotomy. Relative to traditional statistics, AI often outperforms, but at a significantly higher computational cost. But there are also nearly a quarter of cases where AI is both more expensive and performs worse than traditional statistical techniques and this fraction has been stable for a decade. Relative to scientific computing, AI often underperforms, but at lower computational cost. This has begun to change: since 2020, AI’s performance against scientific computing has notably strengthened and it now outperforms on more than half of comparisons. These patterns suggest that AI is therefore not a universal replacement for existing methods, but rather a valuable – and improving – part of a new AI-enabled scientific frontier.

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September 14, 2026
Gabriel Manso, Emma Fu, Neil Thompson (). The AI-Enabled Scientific Frontier. Published in . Retrieved from https://arxiv.org/abs/2609.16258. Accessed .
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@article{,
  title     = { The AI-Enabled Scientific Frontier },
  author    = { Gabriel Manso, Emma Fu, Neil Thompson },
  journal   = {  },
  year      = {  },
  url       = { https://arxiv.org/abs/2609.16258 }
}
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